Dr Chris McMillan is a virologist and vaccinologist whose work focuses on innovative vaccine platforms and advanced delivery technologies. His research spans several pathogens of global health importance, including seasonal and pandemic influenza, flaviviruses, poliovirus, SARS-CoV-2, and emerging viral threats. He works across multiple vaccine modalities, from recombinant proteins and virus-like particles to DNA, mRNA, and self-amplifying RNA platforms. A major research focus is improving vaccine performance through targeted skin delivery using microarray patches (MAPs) to access immune-rich epidermal and dermal layers. By applying spatial transcriptomics and other tissue-scale profiling tools, we aim to map how MAP vaccines interact with the skin and draining lymph nodes in vivo to inform next-generation vaccine design. He is also focusing on new RNA technologies, including self-amplifying RNA systems for both vaccine and therapeutic applications. This work integrates virology, RNA engineering, and spatial immunology to better understand and enhance immune responses at the tissue level.